At CONNECT-TBI, we bring together 30 leading investigators from 13 institutions to generate unparalleled, comprehensive neuropathological and clinical data regarding the connection between traumatic brain injuries (TBI) and neurodegenerative disease. With the collective expertise and harmonized databases that this international collaborative achieves, CONNECT-TBI creates new possibilities to characterize TBI related neurodegeneration (TReND) pathology, and understand the extent and distribution of TReND pathology required to produce neurological dysfunction, the spectrum of symptoms associated with this pathology, and its relationship with wider neurodegenerative diseas