Approaches and Decisions in Acute Pediatric TBI Trial (ADAPT) is an international research study designed to evaluate the impact of interventions on the outcomes of children with severe traumatic brain injury.

CENTER-TBI is a large European project that aims to improve the care for patients with Traumatic Brain Injury (TBI). CENTER-TBI) aims to better characterize TBI and identify the most effective clinical interventions, link patient profiles with effectiveness of treatments (toward “precision medicine”), and improve outcomes via comparative-effectiveness studies. 

At CONNECT-TBI, we bring together 30 leading investigators from 13 institutions to generate unparalleled, comprehensive neuropathological and clinical data regarding the connection between traumatic brain injuries (TBI) and neurodegenerative disease. With the collective expertise and harmonized databases that this international collaborative achieves, CONNECT-TBI creates new possibilities to characterize TBI related neurodegeneration (TReND) pathology, and understand the extent and distribution of TReND pathology required to produce neurological dysfunction, the spectrum of symptoms associated with this pathology, and its relationship with wider neurodegenerative diseas

The aims of the CREACTIVE project are to consolidate the existing network in order to better describe the epidemiology of moderate-severe TBI in 7 countries (Greece and Israel have now joined the consortium); build a prognostic model based on short- and long-term outcome measures; identify the most effective clinical interventions for optimally treating TBI patients, and recognize the determinants of optimal vs suboptimal performance

The Canadian Traumatic Brain Injury Research Consortium was created in December 2015 and is funded by the Canadian Institutes of Health Research and the Ontario Neurotrauma Foundation.The CTRC was created to enhance collaborations amongst Canadian scientists working on different aspects of the continuum of care for traumatic brain injury patients. 

The objective of this project is to create guidelines for the treatment of severe TBI in the absence of ICP monitoring and test them. We propose to derive these guidelines by working with a team of clinicians that practice in austere environments in low-to-middle income countries (LMICs) and routinely make decisions based either on a treatment protocol, their clinical experience, or both. 

The objective of the HEMOglobin transfusion threshold in Traumatic brain Injury OptimizatioN (HEMOTION) trial is to evaluate the effect of two red blood cell transfusion strategies on neurological function at 6 months following TBI. Participant in this trial will be randomly assigned to one of the two following strategies:

LIMBIC-CENC serves as the comprehensive research network for DoD and VA that focuses on the long-term effects of combat-related and military-relevant mild TBI. The Consortium is designed to conduct research that provides clinically relevant answers and interventions for current Service members and Veterans and to develop the long-term solutions to the chronic effects of mTBI.

Pediatric Common Data Elements(Ped-CDE for mTBI and Concussion propose to create a comprehensive, flexible and sustainable assessment battery that will serve to significantly advance clinical care via amalgamated and accessible research evidence. Our overall goal is to enhance our ability to conduct multi-centre research and provide evidence-based care across Canada that will assist in diagnoses and treatment of pediatric mTBI.

Play Game Trial is registered trial, treating children from 8 to 18 years old. It is funded by the Canadian Institutes of Health Research. It is a randomized controlled trial (find out more). The investigators include specialists in paediatrics, neurology, neuropsychology, imagine science, sleep medicine and statistics.

Predicting and Preventing Post-concussive Problems in Pediatrics (5P), led at CHEO and including nine pediatric emergency departments across Canada, enrolled over 3,000 children into this study. All participants were aged 5-18 years old and were evaluated within the first 48-hours after head injury (with most patients presenting within 3 hours of their injury).

The University of Calgary Sport Injury Prevention Research Centre (SIPRC) is committed to achieving a 20% reduction in youth sport and recreational injuries by 2020. We are one of 11 International Research Centres for the Prevention of Injury and Protection of Athlete Health supported by the International Olympic Committee. We will achieve our injury reduction goal by conducting world leading research on injury prevention in youth sport and recreation providing a vibrant and supportive learning environment for faculty, trainees, students and staff building collaborative partnerships with community partners, decision-makers, youth and parents.

SP-TBI is an incubation centre that supports daring Entrepreneurs and helps them in building great Technology Ventures of the future. SP-TBI is an initiative of Bharatiya Vidya Bhavan's Sardar Patel Institute of Technology and is affiliated with Department of Science and Technology, Govt of India. We work as a catalyst for entrepreneurs ensuring they get the best infrastructure, technology support, seed funding, talent pool, mentoring, training and much more. 

The purpose of the TBI-Prognosis study is to develop a prognostic model and clinical prediction rule by using a multimodal approach of different prognostic indicators and their evolution over time in the acute phase of care. This study, taking place in 17 Canadian trauma centers, will improve our ability to prognosticate and identify patients who will benefit from aggressive care in the acute phase, and help preventing erroneous evaluation of prognosis that could have lethal consequences when used to decide to pursue or withdraw life-sustaining therapies.

TBI-REPORTER is a multidisciplinary, multi-centre, UK-wide, national collaboration of over 50 investigators with demonstrable, field leading experience in: epidemiology and cohort management; informatics, record linkage and database interoperability; cognitive and behavioural testing; imaging; biomarker science; genetic risk factors and their analysis; neuropathology, neurosurgery, emergency medicine and neurology research; human physiology, vascular, metabolic and immunological studies; models of human disease; target validation; and experimental medicine.

TEAM TBI is a federally-funded research study at the University of Pittsburgh that investigates the complexity of brain injury, and how targeted interventional strategies may improve outcome and function. After a 3-day evaluation, the study provides you with a customized Toolkit to complement your recommended plan, and follows you for 6 months. At the end of the follow-up period, you will return to the University of Pittsburgh for a repeat evaluation.

The TRACK-TBI (Transforming Research and Clinical Knowledge in TBI) study and the TBI Endpoints Development (TED) Initiative aim to identify and confirm FDA-approved diagnostic and prognostic markers that will lead to successful clinical treatment trials for Traumatic Brain Injury.